Insulin Gene Therapy

Insulin regulates the blood glucose level in mammals Under physiological conditions, the secretion of insulin from fi-cells is closely coordinated with the blood sugar level. An inability to deliver insulin for glucose homeostasis is manifested as diabetes mellitus The underlying basis for improper insulin delivery is either nonfunctional insulin secretory cells or defective regulation. Diabetes associated with damaged insulin producing cells is classified as type 1 or insulin dependent diabetes mellitus (IDDM), whereas type 2 diabetes is due to the relative insulin resistance of the insulin-sensitive tissues and defective secretion of insulin. The current focus of gene transfer technology for diabetes therapy is the development of engineered cell lines that would closely mimic glucose stimulated insulin secretion (42). The use of retroviral-medi-ated gene therapy of (3-cell dysfunction is also being envisioned (42,43). The challenge for insulin gene therapy is to restore the normal level of insulin secretion. Insulin secretory cells are pancreatic cells, however, the expression of insulin in the liver has also been shown to correct the diabetic alterations in a transgenic mouse model (44). Future efforts on the gene therapy front are to clone the genes associated with type 2 diabetes and its associated complications like obesity (45).

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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