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Menetrier's Disease

Menetrier's disease is a rare disorder in children and is probably different from the adult disease. It is typically self-limiting and may be caused by cytomegalovirus (Sferra et al. 1996; Kovacs et al. 1993; Eisenstatt et al. 1995).

Children will present with abdominal pain, nausea and vomiting. Also peripheral edema, asci-tes and pleural effusions are commonly associated with Menetrier's disease due to an associated protein-losing enteropathy.

On barium studies of the upper gastrointestinal tract, markedly enlarged folds (rugae) are typically seen at the gastric fundus along the greater curvature (Fig. 3.14). US can also demonstrate the rugal hypertrophy with thickening of the mucosa. When the stomach is completely filled, however, these thickened folds will collapse. Typically high frequency (8-13 Mhz) linear transducers will be used. Serial US can be used in the follow-up of the disease. CT can also confirm these findings.

Fig. 3.13. a Caustic ingestion: gastric obstruction in a 9-year-old after drinking gasoline. b Esophageal stricture after alkaline ingestion in a 2-year-old
Fig. 3.14. Menetrier's disease: Thickened gastric rugae with no detectable peristalsis in an 8-year-old boy

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