Apoptosis

Apoptosis is a highly orchestrated, genetically programmed process that allows cells to die in a controlled fashion (93,94). All cells have the intracellular machinery necessary for programmed cell death. Whether they use that machinery depends on the cell type, the tissue context, the presence or absence of physiological signals, and the extent to which a cell is damaged or dysfunctional. Like cellular senescence, apoptosis is a double-edged sword. Too little can cause damaged or dysfunctional cells to accumulate, whereas too much can cause tissue atrophy and degeneration.

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