During embryogenesis, apoptosis eliminates damaged or dysfunctional germ cells, superficial cells during tissue morphogenesis, and cells that fail to make the proper functional connections with neighboring cells (95). The key features of apoptosis, and its major regulatory and effector molecules, have been conserved throughout metazoan evolution. However, the number and complexity of proteins and reactions that regulate and execute apoptosis have increased greatly during vertebrate evolution (96). Further, in complex organisms, apoptosis is important for maintaining tissue homeostasis, and for eliminating dysfunctional, damaged, and/or potentially cancerous cells throughout life (93,97).

An important function of apoptosis is to provide a mechanism for eliminating unwanted cells without cell lysis. This is important because cell lysis frequently results in local tissue destruction, owing to the release of degradative enzymes from the lysed cells and the inflammation reactions that it frequently elicits. Thus, apoptosis allows organisms to remove damaged or dysfunctional cells with minimal collateral damage to the tissue. In postmitotic tissues, where cell proliferation cannot replace lost cells, apoptosis minimizes the cell loss. In renewable tissues, where cell proliferation can replace cells that are lost, apoptosis is an important mechanism for maintaining the size, integrity, and health of the tissue.

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook

Post a comment