Stress Resistance

A common correlate of delayed aging is increased stress resistance (160,175). This is true for both simple and complex animals. For example, as noted earlier, cells from long-lived mice are resistant to multiple stresses (162). In addition, animals engineered to be stress resistant tend to be long lived. There are several examples of this phenomenon in simple animals, but fewer examples in mammals (160,175).

One important example in mammals is the germ-line

Ctjp cup disruption of p66 in mice (176). p66 , an isoform of the signaling adaptor protein SHC, has been shown to participate in the regulation of mitochondrial membrane potential, thereby indirectly controlling the level of cellular oxidative stress (177). Cells from mice that lack p66SHC expression are resistant to oxidative stress, evident as a marked reduction in the level of apoptosis. Moreover, the mice themselves live about 30% longer than wild-type control mice (176). Future research will very likely create additional mouse models in which stress-protective proteins such as chaperones are overexpressed to test the idea that stress resistance and longevity are as directly linked in mammals as they are in simple model organisms.

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Staying Young

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