Therapeutic Strategies Based on the Amyloid Connection

Based on this amyloid hypothesis (Chapter 6), several therapeutic strategies have been proposed. Although therapeutic applications are still experimental, a list of these putative strategies may help to better understand the role of amyloid in AD. Therapeutic strategies intend n to block delivery to the brain, by the bloodstream, of APP

molecules ultimately responsible for the Ab deposits; n to inhibit the secretases that cleave APP to produce the Ab peptide;

n to delay the formation of Ab deposits by interfering with the formation of fibrillar, cytotoxic amyloid filaments; n to interfere with activation of macrophages, microglia, and cytokine release that contribute to the inflammatory reaction surrounding the plaques; and n to block the Ab molecules on the surface of neurons to prevent their toxic action.

How to Stay Young

How to Stay Young

For centuries, ever since the legendary Ponce de Leon went searching for the elusive Fountain of Youth, people have been looking for ways to slow down the aging process. Medical science has made great strides in keeping people alive longer by preventing and curing disease, and helping people to live healthier lives. Average life expectancy keeps increasing, and most of us can look forward to the chance to live much longer lives than our ancestors.

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