Therapeutic Strategies Based on the Amyloid Connection

Based on this amyloid hypothesis (Chapter 6), several therapeutic strategies have been proposed. Although therapeutic applications are still experimental, a list of these putative strategies may help to better understand the role of amyloid in AD. Therapeutic strategies intend n to block delivery to the brain, by the bloodstream, of APP

molecules ultimately responsible for the Ab deposits; n to inhibit the secretases that cleave APP to produce the Ab peptide;

n to delay the formation of Ab deposits by interfering with the formation of fibrillar, cytotoxic amyloid filaments; n to interfere with activation of macrophages, microglia, and cytokine release that contribute to the inflammatory reaction surrounding the plaques; and n to block the Ab molecules on the surface of neurons to prevent their toxic action.

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