Clinical Comorbidity Underlined by Overlapping Biological Mechanisms

Sleep is altered in a variety of mental disorders, both as a consequence of the illness and secondary to pharmacological treatment. Mania and anxiety disorders can lead to sleep decrease, whereas anergic depression and negative-symptoms schizophrenia can lead to increases in the duration of sleep. As one of the few objective parameters to be investigated during a psychiatric interview, sleep may be viewed as the "temperature" of the psychiatric clinical exam. The extreme phenotype of narcolepsy has led to the identification of a family of brain peptides called hypocretins as involved in sleep regulation. Another promising line of research is represented by clock genes. Clock genes regulate circadian rhythms, are highly conserved from plants to man [82] and may be molecular substrates mediating the interface of sleep and psychiatric syndromes.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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