Control of insulin secretion by the pcell

At rest, the KATP channels on the p-cell are open. When blood glucose rises, it enters the cell through a membrane-bound glucose transporter (GLUT2). In the p-cell glucose is phosphorylated by glucokinase, which leads to an increase in ATP/ADP ratio. As ATP rises, the KATP channel closes causing depolarization of the cell, which in turn opens voltage-dependent calcium channels, resulting in an influx of calcium. High calcium in the cytosol stimulates exocytosis of insulin from secretory granules (Figure 3.2).

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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