Occurrence of a123y2 receptors throughout the basal ganglia

The a1/ß2/y32 GABAA receptor subtype is the most abundant subtype in the brain (Benke et al., 2004). Many cell types in the basal ganglia use the "standard" BZl-type a1ß2g2 receptor subtype: neurons in the caudate-putamen (striatum), subs-tantia nigra pars reticulata; globus pallidus and subthalamic nucleus, all use this receptor (see Niddam et al., 1987; Wisden et al., 1989, 1992; Criswell et al., 1997; Chen et al., 2004). The sub-thalamic nucleus, substantia nigra pars reticulata, globus pallidus and ventral pallidum are classic BZ1 sites, having some of the highest densities of [3H]zolpidem binding (Niddam et al., 1987; Duncan et al., 1995).

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