The Mitochondrial Death Pathway

Anas Chalah and Roya Khosravi-Far*

Abstract Mitochondria have long been known to be critical for cell survival due to their role in energy metabolism. However, not until the mid-1990s did it become evident that mitochondria are also active participants in programmed cell death (PCD). This chapter focuses mainly on the role the mitochondria in mammalian cell death and cancer progression and therapy.

Keywords apoptosis, death receptors, mitochondria, bid, membranes, phospholi-pases, cardiolipin

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