Spermine as a Biomarker for Malignant Behavior of Prostatic Cancer

Spermine is present in the prostate in high concentrations 10-20 mM . Several studies suggest that a reduction of spermine levels may result from shifts in cellular behavior of prostatic cancer cells 38-40 . Polyamine measurements in our panel of cultured cells or xenografts of human prostatic cell lines showed that the less differentiated cell lines e.g., PC-324, PC-339 contained clearly less spermine than the tumor cell lines with differentiation characteristics resembling androgen...