Fig. 4. Proposed model for polyamine and polyamine analog activation of SSAT t ra n s c r i p-tion. In the absence of excess polyamines or analogs, Nrf-2 bound to the PRE, but basal transcription remains low. In the presence of inducers, PMF-1 expression increases, binds to Nrf-2, and drives transcriptions of SSAT. However, the possibility exists that yet to be identified transcription cofactors (as indicated by ?) may modify SSAT transcription in response to polyamines and their analogs.
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