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Fig. 8.2 Venn Diagram. The use of multiple types of data is a powerful tool to filter expression arrays.

tion of the genomic subset with the expression subset. Differences in transcription that map to differences in the genome are suspect as sites where mutation has affected a promoter, mRNA stability, or message function. At a more sophisticated level, differences in transcription may soon be mapped to genetic difference marking functional mutations in transcription factors, receptors, or cytokines.

Fig. 8.3 Venn diagram of transcriptome versus genome. Use of transcription patterns to map multiple genomic loci. These Venn diagrams show comparisons of genes (on the right) with transcripts (on the left). The first set of intersects include those genes that are different in sequence (right) versus expression (left), producing the "subsets of interest". The third level set shows the intersec tion of the genomic subset with the expression subset. Differences in transcription that map to differences in the genome are suspect as sites where mutation has affected a promoter, mRNA stability, or message function. At a more sophisticated level, differences in transcription may soon be mapped to genetic difference marking functional mutations in transcription factors, receptors, or cytokines.

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