Microangiopathic hemolytic anemia MAHA

• Intra-arterioiar fibrin which damages RBCs — acquired intravascular hemolysis

• Etiologies: hemolytic-uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP). disseminated intravascular coagulation (DIC), malignancy, malignant HTN. eclampsia HELLP. mech. cardiac valves, infected vascular prostheses

• Diagnosis: schistocytes thrombocytopenia abnormalities associated with specific disorders, eg. T PT in DIC. T Cr in HUS. T LFTs in HELLP

• Treatment: treat underlying abnormality, consider plasma exchange for TTP

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