Overview

Definitions

• Glomerulonephritis (GN) (NEJM 1998:339:888; ioncet 2005.365: 1797)

pathologically: intraglomerular inflammation (ranging from focal proliferative to diffuse proliferative to crescentic) clinically: hematuria w dysmorphic RBCs or RBC casts, • subnephrotic proteinuria often w renal failure. HTN. edema; spectrum of progression tempo: acute GN over days; rapidly progressive GN (RPGN) wks; chronic GN - mos but can have asymptomatic glomerular hematuria

• Nephrotic syndrome: noninflammatory injury to glomerular filtration barrier proteinuria >3.5 g d.alb -:3.5 mg dl. edema. Î cholesterol, lipiduria. hypercoag.

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