Effectiveness of Statins for the Primary and Secondary Prevention of Coronary Heart Disease Proved in Western Countries

Natural Cholesterol Guide

Lower Cholesterol Guide

Get Instant Access

Table 10

Summary of intervention trials with statins which were performed in Western countries

Cholesterol level Primary prevention Secondary prevention normal hyper normal hyper low HDL-C

Risk reduction, % 37 31 24 34 22

Drug lovastatin pravastatin pravastatin simvastatin gemfibrozil

Trial CAPS WOS CARE 4S VA-HIT

Downs et al. Shephard et Sacks et al. Scandinavian Rubins et al.

Survival Study Group [1994]

Our comments: The beneficial effects of statins were proved and their side effects were reported to be tolerable during several years of interventions, although a couple of other statins were withdrawn from the market.

Statins decrease CHD events regardless of the TC and LDL levels

Data taken from Kendall and Nuttall [2002].

Statins decrease CHD events regardless of the TC and LDL levels

Data taken from Kendall and Nuttall [2002].

Coronary Heart Disease Data

Conclusion: Simvastatin produced an approximately 25% reduction in rate of major vascular events irrespective of previous or coexisting disease, irrespective of age and irrespective of gender. Of particular interest, simvastatin produced comparable reductions in vascular events irrespective of the prior LDL and TC.

Our comments: The similar effectiveness in decreasing CHD events regardless of the TC and LDL levels suggests that the benefits obtained from statins are likely to be mediated by mechanisms other than lowering TC and LDL.

Pleiotropic effects of statins exerted mainly through isoprenyl intermediates, and statins' side effects

HMG-CoA reductase

Foods Acetyl-CoA HMG-CoA Mevalonate Isoprenoid intermediates Cholesterol

Statin

Was this article helpful?

0 0
Your Heart and Nutrition

Your Heart and Nutrition

Prevention is better than a cure. Learn how to cherish your heart by taking the necessary means to keep it pumping healthily and steadily through your life.

Get My Free Ebook


Post a comment