Pulse Wave Velocity Correlated Positively with Ischemic Changes in Electrocardiogram but Not with Total Cholesterol Levels

Fig. 46

Positive correlation of PWV with ischemic ECG changes

Reproduced from Suzuki et al. [1987], with permission from the Japan Atherosclerosis Society.

Conclusion: The incidence of ischemic ECG changes increased exponentially with PWV values in men, suggesting that a progressive rise of PWV value preceded ischemic ECG change.

Our comment: This measure of vascular dysfunction may be useful as an early intermediate biomarker prior to a severe clinical CHD event or death.

PWV increased along with aging and was not correlated with TC

Reproduced from Suzuki et al. [1987], with permission from the Japan Atherosclerosis Society.

Male

Female

Female

-140 -180 -220 -260-300 301 -140-180-220 -260 -300 300-TC (mg/dl)

60 years 50 years 40 years 30 years

The incidence of ischemic ECG changes with each serum lipid value showed weak positive correlations for TC of women in their 30s to their 50s and stronger correlations for men.

Conclusion: The PWV value indicative of organic changes in the aorta tended to be higher for each age group of both genders, but it was not correlated with TC.

Our comments: PWV correlates with stiffness of blood vessels (degree of atherosclerosis), and the PWV value increased with aging. Factors other than vessel stiffness, e.g. blood pressure, are likely to affect the PWV, but atherosclerosis measured by PWV is independent of TC values; no significant association was observed between PWV and TC level.

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