Absorption Of Drugs Across The Oral Mucosa

The oral cavity is the point of entry for oral drug formulations but usually their contact with the oral mucosa is brief. In order to take advantage of some of the properties of the oral mucosa or to locally treat the mucosa, delivery systems have been designed to prolong residence in this area. The total surface area available for drug absorption is quite limited, being only approximately 100 cm2. Absorption of drugs through the buccal mucosa was first described by Sobrero in 1847 who noted...