Skin condition and structure varies with age. The stratum corneum is not fully developed in neonates and this has been used to advantage in the administration of transdermal theophylline and caffeine18. It can also pose a major problem since externally applied materials, such as antiseptics and disinfectants, can be absorbed easily. Pre-term infants have very little barrier function, since this does not develop until 9 months after conception. In older people the stratum corneum thickens and is less hydrated, increasing its barrier function.
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If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.