C

Caco-2 cell lines 128

Caecum 144 Animal 145 Caffeine 173 Calcitonin 210, 280 Calcium 134

Calcium channel blockers 55 Calcium pectate 164 Calveolated cells. See tuft cells Candida 54

Capillary basement membrane 24 Capsules

Correct dosing 65 Hard gelatin 94 Oesophageal transit 63 Soft gelatin 94 Soft jelly 278 Carbamazepine 170, 173 Carbohydrates 119 Carbomers 264 Carbon dioxide 150 Carbonic anhydrase 80 Carbonic anhydrase inhibitors 268 Carbopols 212, 264 Carboxylesterase 43, 202 Carboxymethylcellulose 55, 262 Carbromal 173

Cardia. See gastro-oesophageal junction Cardiac glands 60 Cardiovascular active drugs 173 Caries 39, 54

Carrier mediated diffusion. See facilitated diffusion Carteolol 265 Castor oil 124 Cavernous sinusoids 201 Cell junctions 8 Cell membranes 2

Transport across 12 Cells of Cajal 61 Cellulose 150

Cellulose acetate phthalate 66, 264 Cementum 39 Ceramides 46, 183, 191 Cerebrospinal fluid 32 Cervix 272

CFTR See Cystic fibrosis transmembrane conductance regulator Charcoal 43 Charcoal block 237 Chewing gum 52 Chief cells 79 Chitosan 213 Chloramphenicol 257 Chlorhexidine 53 Chloride ions 149 Chlormadinone acetate 278 Chlorobutol 214 Chlorofluorocarbon 233

Cholecystokinin 113, 148, 152 Cholera 117

Cholesterol 46, 112, 115, 183

Bile salts 116 Cholinergic agonists 102, 214 Chondroitin 263 Choroid plexi 32, 252 Chronic alcoholism 70 Chylomicrons 115, 120 Chyme 117, 118, 122 Chymotrypsin 119 Cigarette smoking 206, 231, 242 Ciliogenesis 276 Cilioinhibition 213 Ciliotoxicity 213 Cimetidine 130, 133 Cinnarizine 100 Citrate 50 Clara cells 225 Clonazepam 169 Clonidine 187

Codeine 32, 135, 156, 172, 173 Coffee 156 Collagen 7, 184, 252 Shields 266 Colloidal delivery 33 Colon

Anatomy and physiology 144 Bacteria 147, 150 Blood supply 147 Drug absorption 157 Co-medication 165 Disease 165 Drug delivery 157 Electrical activity 152 Environment 149 Humoral control 148 Interspecies variation 145 Motility 151, 153 Mucosa 146

Nervous and control 148 Particle size 159 pH 150 Structure 146 Targeting 161, 162, 163 Temporal factors 161 Transit of dose forms 156, 158 Transit time 154 Water and electrolytes 149 Columnar cells 8 Columnar epithelium 8, 111 Upper airway 225 Conjunctiva 252

Drug penetration 259 Conjunctival fornix 255 Connective tissue 39 Constipation 92

Contraceptive pill 134 Copper 279 Cornea 251, 252, 257 Corneocyte 183

Corticosteroids See also Steroids 53, 173

Cotransport 14

Cotton pledgets 63

Cough 229

Creams 48, 189, 278

Crohn's disease 147, 165

Crypt cells 117

Crypts of Lieberkühn 16, 113, 146 Crystal suspension 27 Crytococci 54 Cushing's syndrome 214 Cyanoacrylate microspheres 33 Cyclacillin 14 Cyclic AMP 10 Cyclodextrins 164. 187, 192 Cyclosporin A 130 Cydot 52

CYP 3A4 See cytochrome P450:3A4 Cysteinyl leukotriene receptors 244 Cystic fibrosis 244

Cystic fibrosis transmembrane conductance regulator 117 Cytochrome p-450 dependent monooxygenases 202 Cytochrome p450 128 3A4 131, 134 Cytoplasm 2 Cytosis 15 Cytosol 7

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