Vaginal delivery has the advantage that self-insertion and removal of delivery devices is possible. This route does avoid first-pass metabolism, but the mucosa is not as permeable as the uterus to peptides and proteins and the variability in bioavailability is too high to be used clinically. In contrast, the uterus appears to be very permeable to a wide variety of substances, but insertion and removal of devices has to be performed by medically qualified personnel. Possible consequences of pregnancy occurring whilst the devices are in situ has to be studied thoroughly since the local concentration of the drug is likely to be high. Drugs absorbed from the uterus also avoid first-pass metabolism.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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