Oesophageal adhesion of dosage forms is surprisingly common and can cause problems of local ulceration or delayed drug absorption. In general, there are several factors which predispose a formulation to adhere: a) shape of dosage form, b) size of dosage form, c) position of subject, d) volume of water with which the dosage form is administered, e) surface characteristic of the dosage form. It is important to emphasise the correct method of swallowing tablets, particularly in high risk groups. New technologies are emerging which can locally delivery drugs to treat disorders of the oesophagus.
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