Reliable delivery of drugs to the proximal colon is one of the key areas of research in drug delivery at the present time. It is hampered by the relative inaccessibility and the difficulty in producing in vitro models which mimic the environment of the colon. Results from the studies of sustained release dosage forms using pharmacokinetic and scintigraphic techniques indicate that, for once a day dosing to be successful, the drug must be absorbed from the ascending colon to maintain therapeutic levels.
Oral dosing is the preferred route of administration for drug delivery to the proximal colon. Consequently the design of peroral controlled-release dosage forms has to take into account a plethora of factors which may influence the transit of the delivery system and the consequent degree of drug absorption.
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