Conclusions

The attractiveness of the buccal route of dosing is the avoidance of first-pass metabolism of drugs. Drugs which can successfully be delivered by this route need to be highly active and able to produce a pharmacological response in small amounts. Absorption appears to be somewhat erratic due to an unpredictable salivary flow washing drug into the stomach, which is then available for absorption via the small intestine. Possibly the degree of plaque formation in the mouth and hence variability in junctional epithelium exposed also affects absorption to a degree.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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