Drug Absorption Through The Vaginauterus

A wide range of drugs have been studied for vaginal absoprtion. These include steroid hormones such as progesterone and oestrogen, prostaglandins, iodides and salicylates5, peanut proteins, bacterial antigens and poly vinyl alcohol (m. w. 25,000 Daltons)6. Insulin, hydrocyanic acid, iodides, strychnine, pilocarpine, atropine, quinine and oxyquinolone are rapidly absorbed from cat and dog vaginas5. Quinine and phenol red are absorbed slowly and methylene blue only in very small quantities.

A recently reported observation is that drugs administered intravaginally accumulate in uterine tissue. This has been reported for danazol, terbutaline and progesterone7-9. These findings have lead to the hypothesis that there is a direct transport mechanism from vagina to uterus or a "uterine-first pass effect"9.

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook

Post a comment