Drug Absorption Through The Vaginauterus

A wide range of drugs have been studied for vaginal absoprtion. These include steroid hormones such as progesterone and oestrogen, prostaglandins, iodides and salicylates5, peanut proteins, bacterial antigens and poly vinyl alcohol (m. w. 25,000 Daltons)6. Insulin, hydrocyanic acid, iodides, strychnine, pilocarpine, atropine, quinine and oxyquinolone are rapidly absorbed from cat and dog vaginas5. Quinine and phenol red are absorbed slowly and methylene blue only in very small quantities.

A recently reported observation is that drugs administered intravaginally accumulate in uterine tissue. This has been reported for danazol, terbutaline and progesterone7-9. These findings have lead to the hypothesis that there is a direct transport mechanism from vagina to uterus or a "uterine-first pass effect"9.

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