Drugformulation Induced Ulceration

Acute and/or chronic lesions on the gastric mucosa may result from the ingestion of alcohol, and some drugs such as anti-inflammatory drugs, reserpine, histamine and caffeine. Salicylates are often reported to produce dyspepsia and gastric ulcers due to their widespread use. A single dose of 2 aspirin tablets produced haemorrhaging in the stomach of normal volunteers within 1 hour of ingestion, continued intake (2 tablets every 6 hours) resulted in gastric erosions in all subjects and duodenal erosions in 50% of the subjects104. Patients who require aspirin on a regular basis should take enteric coated or adequately buffered preparations.

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