Drugformulation Induced Ulceration

Acute and/or chronic lesions on the gastric mucosa may result from the ingestion of alcohol, and some drugs such as anti-inflammatory drugs, reserpine, histamine and caffeine. Salicylates are often reported to produce dyspepsia and gastric ulcers due to their widespread use. A single dose of 2 aspirin tablets produced haemorrhaging in the stomach of normal volunteers within 1 hour of ingestion, continued intake (2 tablets every 6 hours) resulted in gastric erosions in all subjects and duodenal erosions in 50% of the subjects104. Patients who require aspirin on a regular basis should take enteric coated or adequately buffered preparations.

Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment