Druginduced effects on gastric emptying

Drugs contained within the formulations may also alter gastric motility. For example adrenergic agonists, particularly E2-agonists such as salbutamol, delay gastric emptying. In asthmatic subjects an variable quantity of the inhaled drug may be swallowed, and hence even though the drug is not taken by the oral route, it may still have an effect on the gastric emptying of other drugs. Tricyclic antidepressants and some anti-Parkinsonian drugs depress gastrointestinal motility. Dopaminergic antagonists e.g. domperidone, and cholinergic agonists e.g. bethanechol, enhance gastric motor activity.

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