Individual variation can be as severe a problem as for other drug delivery systems, for example the absorption of hydrocortisone can show nearly a ten-fold variation between individuals17. Thus dosage must be titrated to achieve a therapeutic benefit and the transdermal system does have the advantage in this respect that treatment can be stopped rapidly if too great a response is observed. It is straightforward to adjust the dose rate by varying the surface area of the device, although there are obviously practical limits to this.
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