Nasal Drug Delivery

ANATOMY AND PHYSIOLOGY Nasal epithelia Nasal lymphatic system Nasal secretion The nasal cycle

Mucociliary clearance of inhaled particles

Measurement of clearance Pathological effects on mucociliary function Rhinitis Asthma Sinusitis

Kartegener's syndrome Sjögrens Syndrome Structural dysfunction External factors affecting mucociliary clearance Chemical-induced changes

Other factors which affect mucociliaiy clearance INTRANASAL ADMINISTRATION OF DRUGS Drugs administered for local action Drugs administered for systemic effect Penetration enhancers DRUG DELIVERY SYSTEMS AND DEPOSITION PATTERNS Mechanisms to increase nasal residence time of formulations Viscosity modifiers Bioadhesive polymers. Bioadhesive microspheres Excipient and drug effects on clearance Effect of formulation pH INTERSPECIES COMPARISONS CONCLUSIONS REFERENCES

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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