Nasal Drug Delivery
ANATOMY AND PHYSIOLOGY Nasal epithelia Nasal lymphatic system Nasal secretion The nasal cycle
Mucociliary clearance of inhaled particles
Measurement of clearance Pathological effects on mucociliary function Rhinitis Asthma Sinusitis
Kartegener's syndrome Sjögrens Syndrome Structural dysfunction External factors affecting mucociliary clearance Chemical-induced changes
Other factors which affect mucociliaiy clearance INTRANASAL ADMINISTRATION OF DRUGS Drugs administered for local action Drugs administered for systemic effect Penetration enhancers DRUG DELIVERY SYSTEMS AND DEPOSITION PATTERNS Mechanisms to increase nasal residence time of formulations Viscosity modifiers Bioadhesive polymers. Bioadhesive microspheres Excipient and drug effects on clearance Effect of formulation pH INTERSPECIES COMPARISONS CONCLUSIONS REFERENCES
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