P

P-aminoclonidine 260 P-glycoprotein 32, 130-131, 134 Palate 38 Palmitic acid 4 Pancreas 116

secretion 116 Paneth cells 113, 147 Papillary layer 184 Paracetamol 100, 130, 171, 173 Parenteral administration Drug delivery 19 Drug distribution 30 Parietal cells 7, 14, 79, 80 Particle size

Lung 240

Nasal deposition 210 Particulates 24, 265 Partition coefficient 12 Passive diffusion 12 Peanut proteins 277 Pectins 126, 155, 164 Pectoral See muscle Pellets See also multiparticulates Penbutolol 260

Penetration enhancers 191, 210

Oral mucosa 47 Penicillin 133, 135, 214 Pepsin 79, 82 Pepsinogen 79, 82 Peptides

Delivery 209, 213

Perfusion

Eye 262 Perimysium 26 Periodontal disease 54 Periodontitis 53 Periodontosis 53 Peritoneum 110 Persorption 16 Pessaries 278 Pethidine 54 Petrolatum 264 Petrolatum based jelly 262

Peyer's patches 110, 114, 128, 151 pH 156, 192

Colon 150 Eye 257 Faecal 154 Small intestine 129 Vagina 275 pH-partition hypothesis 13 Phagocytosis 16 Pharmacokinetics

Lung deposition 243 Phenobarbital 170 Phenol red 277 Phenylalanine 209 Phenylephrine 208 Phlebitis 22 Phonation 222 Phosphatidylcholine 3, 7 Phosphatidylethanolamine 3, 7 Phosphatidylinositol 3 Phosphatidylserine 3 Phosphoglucomutase 202 Phospholipid 7, 115

Stealth 29 Pigmentation 258 Pigs 103

Pilocarpine 257, 258, 265, 277 Pituitary hormones 7 Plaque 54

Plasma membrane 2 Platelets 82 Plicae semilunares 147 Pluronic 264

pMDI See pressurized metered dose inhalers Polyacrylic acid 279 Polyalkylene glycols 262 Polycarbophil gel 279 Polyethylene 24, 174 Polygonal cells 251 Polyps

Eosinophil 206 Neutrophil 206 Polysaccharides 7 Polysorbates 33 Polystyrene particles 25 Polyurethane 24 Polyvinyl alcohol 263, 277 Polyvinylpyrrolidone 262 Positron emission tomography 237 Potassium chloride 136 Potassium iodide 244 Potassium ions 149 Prazosin 135 Precorneal tear film 253 Prednisolone 173 Pregnancy 275

Gastric emptying 92 Preoperative medication 170 Preservatives

Eye 261

Pressurized metered dose inhalers 211

Radiolabelling 238 Progesterone 148, 277, 279 Progestin 278 Prolapse 277 Proline 119

Promethazine 172, 173 Propranolol 135, 214, 260 Propylene glycol 191 Prostaglandins 7, 82, 208, 230, 277 Prostep 190

Protein binding 31, 129

Eye 258 Proteins 245 Proteoglycans 82, 184 Ptyalin 43 Puberty

Delayed 53 Pulmonary See also lung Circulation 20 Deposition patterns 241 Parenchyma 224 Pulsincap™ 162

PVA (polyvinyl alcohol) gel 266 Pylorectomy 88 Pyloric portion 76 Pyloroplasty 88 Pyrogens 20

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