Patient Preference And Ease Of Swallowing

Patients prefer taking capsules to large oval or round tablets, partly due to the smooth surface and the shape which assists swallowing. The difficulty in swallowing large round tablets increases over the age of 60 years when up to 60% of healthy subjects may report a problem. There is a tendency amongst these patients to chew the tablets and capsules or to open the capsule and disperse the pellets in food or a drink. This can lead to an unknown loss of a proportion of the dose. Chewing formulations will destroy the integrity of any surface coating and it is a particular problem for sustained or controlled release formulations that are designed to be swallowed intact. Chewing will destroy matrix structures and increase the surface area available for drug dissolution.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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