STRUCTURE AND FUNCTION OF THE PULMONARY SYSTEM The lung Upper airway
Structure of the tracheo-bronchial tree Epithelium
Upper airways Bronchi and bronchioles Alveoli
Alveolar-capillary membrane Lung permeability Lung mucus Lung defenses Lung surfactant Blood supply Lymphatic system Nervous control
Cough reflex Biochemical processes which occur in the lung Breathing Respiratory disease Asthma
DOSAGE FORMS FOR PULMONARY DRUG DELIVERY Pressurized inhalation aerosols Dry powder inhalers Nebulizers
Spacer devices and ancillary equipment ASSESSMENT OF DEPOSITION BY GAMMA SCINTIGRAPHY Choice of radiolabel Labeling inhalation formulations Labeling dry powder inhalers Validation
FACTORS AFFECTING PARTICLE DEPOSITION IN THE LUNG Physicochemical properties Deposition patterns from different dose forms Physiological variables
Inhaler technique Effects of disease DRUG ABSORPTION PHARMACOKINETICS
DRUGS ADMINISTERED VIA THE PULMONARY ROUTE Anti-allergy agents Beta receptor agonists Adrenocorticosteroids Leukotriene inhibitors Other bronchodilating agents Mucolytics
Systemically-absorbed drugs REFERENCES
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