The rectal route of drug administration offers several advantages, including a) a relatively large dosage form can be accommodated in the rectum b) the rectal route is safe and convenient for elderly and young patients c) drug dilution is minimized as the residual fluid volume is low d) the rectum is generally empty e) absorption adjuvants have a more pronounced effect than in the upper gastrointestinal tract f) degradative enzymes in the rectal lumen are at relatively low concentrations g) therapy can easily be discontinued h) first-pass elimination of drug by the liver is partly avoided
The rectal route is often used when administration of dosage forms by mouth is inappropriate, for example, in the presence of nausea and vomiting, in unconscious patients, if upper gastrointestinal disease is present which could affect the absorption of the drug, or if the drug is unpleasant tasting or acid-labile.
Was this article helpful?
Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...