1. Wolff E. Mucocutaneous junction of lid-margin and distribution of tear fluid. Trans. Opthal. Soc. UK 1946-66:291-308,

2. Prydal JI, Kerr-Muir MG, Dilly PN. Comparison of tear film thickness in three species determined by the glass fibre method and confocal microscopy. Eye 1993; 7:472-475.

3. Tiffany JM, Winter N, Bliss G. Tear film stability and tear surface tension. 1989; 8:507515.

4. Lee VHL, Robinson JR. Disposition of pilocarpine in the pigmented rabbit eye. Int. J. Pharmaceut. 1982; 11:155-165.

5. Lee VHL. Esterase activities in adult rabbit eyes. J. Pharmaceut. Sci. 1983; 72:239-244.

6. Ahmed I, Gokhale RD, Shah MV, Patton TF. Physicochemical determinants of drug diffusion across the conjunctiva, sclera and cornea. J. Pharmaceut. Sci. 1987; 76:583586.

7. Chien DS, Homsy JJ, Gluchowski C, TangLiu DS. Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN190342, and clonidine in rabbit eyes. Cur. Eye Res. 1990; 9:1051-1059.

8. Brown RH, Lynch MG. Drop size of commericial glaucoma medications. Am. J. Ophthalmol 1986; 102:673-674.

9. Reducing the size and toxicity of eyedrops. 10th National science writers seminar in ophthalmology: 1988; Arlington.

10. Whitson JT, Love R, Brown RH, Lynch MG, Schoenwald RD. The effect of reduced eyedrop size and eyelid closure on the therapeutic index of phenylephrine. Am. J. Ophthalmol. 1993; 115:357-359.

11. Lal A, Kumar V. The therapeutic response to topical instillation of different drop volume of tropicamide in humans. Afro-Asian J. Opthalmol. 1995; 14:15-18.

12. Martini LG, Embleton JK, Malcolmson RJ, Richard J, Wilson CG. The use of small volume ocular sprays to improve the bioavailability of topically applied ophthalmic drugs. Europ. J. Pharmaceut. Biopharm. 1997; 44:121-126.

13. Snibson GR, Greaves JL, Soper NDW, Prydal JI, Wilson CG, Bron AJ. Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy. Eye 1990; 4:594-602.

14. Silver FH. Biomaterials used in ophthalmology. Biomaterials, Medical Devices and Tissue Engineering. London: Chapman and Hall, 1993:120-152.

15. Wilson CG, Zhu YP, Frier M, Rao LS, Gilchrist P, Perkins AC. Ocular contact time of a carbomer gel, Geltears®, in human. Br. J. Ophthalmol. 1998; 82:1131-1134.

16. Greaves JL, Wilson CG, Rozier A, Grove J, Plazonnet B. Scintigraphic Assessment of an Ophthalmic Gelling Vehicle in Man and Rabbit. Curr. Eye Res. 1990; 9:415-420.

17. Meseguer G, Buri P, Plazonnet B, Rozier A, Gurny R. Gamma scintigraphic comparison of eyedrops containing pilocarpine in healthy volunteers. J. Ocular Pharmacol. Therapeut. 1996; 12:481-488.

18. Joshi A, Ding S, Himmelstein KJ. U.S. Patent 5 252 318. 1993.

19. Greaves JL, Wilson CG, Birmingham AT. Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects. Br. J. Clin. Pharmacol. 1993; 35:188-192.

20. Sieg JW, Triplett JW. Precorneal retention of topically instilled micronized particles. J. Pharmaceut. Sci. 1980; 69:863-864.

21. Schoenwald RD, Stewart P. Effect of particle size on ophthalmic bioavailability of dexamethasone suspensions in rabbits. J. Pharmaceut. Sci. 1980; 69:391-394.

22. Olejnik O, Weisbecker CA. Ocular bioavailability of topical prednisolone preparations. Clin. Therapeut. 1990; 12:2-11.

23. Gurny R. Preliminary study of prolonged acting "drug" delivery system for the treatment of glaucoma. Pharm. Acta. Helv. 1981; 56:130-132.

24. Marcha-Heussler L, Sirbat D, Hoffman M, Maincent P. Poly (epsilon-caprolactone) nanocapsules in carteolol ophthalmic delivery. Pharmaceut. Res. 1993; 10:386-390.

25. Shofner RS, Kaufman HE, Hill JM. New Horizons in ocular drug delivery. In: Ophthalmol. Clin. N. Am. Kooner TJ (ed) Philadelphia. W.B.Saunders Co., 1989.

26. Greaves JL, Wilson CG, Birmingham AT, Richardson MC, Bentley PH. Scintigraphic studies on the corneal residence of a New Ophthalmic Delivery System (NODS): Rate of clearance of a soluble marker in relation to duration of pharmacological action of pilocarpine. Br. J. Clin. Pharmacol. 1992; 33:603-609.

Chapter Twelve

Vaginal and Intrauterine Drug Delivery


Blood and nerve supply Uterine and vaginal fluid pH

Enzymatic activity Mucus

Menstruation Menopause


Creams and gels Pessaries or tablets Vaginal rings

Bioadhesive delivery systems Intrauterinedevices CONCLUSION REFERENCES

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