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Chapter Twelve

Vaginal and Intrauterine Drug Delivery

ANATOMY AND PHYSIOLOGY Mucosa

Blood and nerve supply Uterine and vaginal fluid pH

Enzymatic activity Mucus

Menstruation Menopause

Disorders of the vagina DRUG ABSORPTION THROUGH THE VAGINA/UTERUS DRUG DELIVERY Vaginal

Creams and gels Pessaries or tablets Vaginal rings

Bioadhesive delivery systems Intrauterinedevices CONCLUSION REFERENCES

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