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Drug absorption varies greatly with site of application. Hydrocortisone, for example, penetrates the scrotum 40 times more rapidly than the forearm or back, the commonly used application sites. Heavily keratinised sites, notably the arch of the foot, are several times less efficient than the forearm. This pattern appears to apply to most drugs and offers the interesting possibility of titrating the dose by varying the position of the transdermal device. Patients who experience local irritation may re-site devices, which causes a problem when areas are chosen with very different absorption characteristics. Indeed, recently, it has been suggested that the site of application of the delivery device should be varied to reduce the skin sensitivity16.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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