Temporal factors

Once-a-day dosing for a sustained release medication is usually taken to mean administration in the morning, and for a typical individual, housekeeper sequences clear the stomach of material by 1100 hours. The formulation would then arrive in the ascending colon by 1300-1400 hours. Intake of a light lunch will increase colonic motility via activation of the gastrocolic reflex. This has the effect of shortening the time of contact with the ascending colon. If the same once-a-day medication is administered between 1600 and 1700 hours, the unit will leave the stomach before the main meal at night and will be in the ascending colon by the time the patient has retired to bed. At night, the motility of the ascending colon will become quiescent. Motility increases in the first 30 minutes after waking, with the initiation of high amplitude contractions. In the majority of the population, this is causes an urge to void, and the colonic activity moves the contents of the proximal region to the distal colon. Consequently, afternoon dosing results in prolonged contact with the proximal colon compared to morning dosing.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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