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DOTATOC

labeled microspheres of such a size that can be trapped by the first capillary bed they encounter [36]. For this purpose, commercial kits of biodegradable albumin colloids are available for 99mTc labeling. As mentioned earlier, however, the labeling with PET radionuclides offers a distinct advantage over single-photon radionu-clides. 66Ga- and 68Ga-labeled albumin microspheres have been studied. The microspheres can be labeled directly with gallium, or through a bifunctional chelator that is covalently bound to the microspheres. 68Ga-labeled microspheres have been used as regional pulmonary and cerebral blood flow agents [54-57]. However, for studying slow dynamic processes such as lymphatic transport, 66Ga-labeled albumin colloids have been proposed [58].

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