Fluorine-18 is currently the most utilized PET radiohalogen as a result of its relatively facile production in large quantities, its convenient half-life, and its nearly optimal decay properties. Efficient incorporation of the 18F-radiolabel into a variety of radiopharmaceuticals is possible using either nucleophilic routes with high specific activity [18F]fluoride or electrophilic routes with lower specific activity [18F]fluorine. The longer half-lives of 76Br and 124I can provide advantages over 18F to image slower physiological processes, but the production of these radiohalogens is more demanding and their decay properties are more complex than those of 18F. Thus, 18F has become the radiohalogen of choice for a variety of PET imaging applications.
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