Clinical gene therapy has been initiated relatively recently and will require many additional refinements prior to being considered a successful therapeutic modality. In the near future the field will have to overcome several problems, such as finding appropriate therapeutic gene(s) and utilizing appropriate delivery vectors for efficient and specific targeting. New methods of molecular engineering, probe design and imaging technology are expected to generate many new imaging approaches. Imaging molecular events with PET should revolutionize current approaches of diagnosing and monitoring diseases treated with gene therapy.
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