A number of PET tracers have been developed and validated allowing the in vivo monitoring of interaction or binding to specific receptors and enzyme systems. This gives the opportunity of measuring the number of free receptors in a certain anatomical structure on one occasion, and evaluating changes in this receptor population induced during drug treatment. For drugs where a defined biochemical target is assumed, this gives possibilities to verify that the target system is indeed affected and to assess the degree of interaction. Biochemical systems other than the primary target might also be monitored for assessment of potential side effects.
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