Early on, EPA identified aniline compounds as a concern for health effects in workers and the public. Aniline compounds are used to make dyes and are a feed material for a large number of organic chemical products, including isocyanates, rubber processing chemicals, hydroquinone (used to manufacture drugs), herbicides, synthetic fibers, and photographic chemicals. In 1988 EPA issued "Testing Consent Orders" (EPA 1988) for aniline and seven substituted anilines (anilines in which halogen atoms are substituted for hydrogen atoms) pursuant to its authority under TSCA. The Testing Consent Order mandates testing for various categories of effects, depending on the compound. Testing includes the following types of effects: chronic health effects with emphasis on blood and nervous system disorders, teratogenicity, carcinogenicity, mutagenic effects, epidemiology studies, and chemical fate and environmental effects testing. The testing requirements for aniline (CAS: 62-53-3) were withdrawn July 27, 1994 (53 FR 31804). However, testing results for various aniline compounds have been compiled and listed on their Web site (EPA 2005a). Table 15.3 is a partial listing of the results available for aniline.
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