Maternal and perinatal outcome

Maternal and perinatal outcomes in pre-eclampsia are usually dependent on one or more of the following: gestational age at onset of pre-eclampsia, as well as at time of delivery, the severity of the disease process, the presence of a multifetal gestation, and the presence of pre-existing medical conditions such as pregestational diabetes, renal disease or thrombophilia. Perinatal mortality and morbidities, as well as the rates of abruptio placentae, are substantially increased in women with severe pre-eclampsia (Sibai, 2003). The rate of neonatal complications is markedly increased in those who develop severe pre-eclampsia in the second trimester, whereas it is minimally increased in those with severe pre-eclampsia beyond 35 weeks' gestation.

Severe pre-eclampsia is also associated with an increased risk of maternal mortality (0.2%), and increased rates of maternal morbidity (5%) with conditions such as convulsions, intracranial hemorrhage/infarction, pulmonary edema, acute renal or liver failure, liver hemorrhage, pancreatitis, and disseminated intravascular coagulopathy (DIC). These complications are usually seen in women who develop pre-eclampsia before 32 weeks' gestation and in those with pre-existing medical conditions (Sibai, 2003).

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