Nitric oxide in preeclampsia

Chronic inhibition of NO synthesis with L-NMMA in pregnant rats results in hypertension, protein-uria and fetal growth restriction, a syndrome mimicking pre-eclampsia (Yallampali and Garfield, 1993). Simultaneous infusion of l-arginine has been shown to reverse the hypertension and growth restriction (Molnar et al., 1994; Yallampali and Garfield, 1993). It would be expected that endothelial dysfunction in pre-eclampsia would lead to impaired NOS activity. Due to methodological limitations, however, human studies have not reached a consensus on how NOS activity is altered during pre-eclampsia.

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