Nitric oxide in preeclampsia

Chronic inhibition of NO synthesis with L-NMMA in pregnant rats results in hypertension, protein-uria and fetal growth restriction, a syndrome mimicking pre-eclampsia (Yallampali and Garfield, 1993). Simultaneous infusion of l-arginine has been shown to reverse the hypertension and growth restriction (Molnar et al., 1994; Yallampali and Garfield, 1993). It would be expected that endothelial dysfunction in pre-eclampsia would lead to impaired NOS activity. Due to methodological limitations, however, human studies have not reached a consensus on how NOS activity is altered during pre-eclampsia.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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