In the last few years, a number of rodent models have been reported in which pregnant females develop the classic signs of pre-eclampsia including hypertension, proteinuria and renal glomerulo-sclerosis, and several others that show at least some of the associated features such as fetal growth restriction (Table 14.2). While each of the models is interesting in its own way, collectively they give us insights into what factors are and are not sufficient to initiate the pathogenesis of pre-eclampsia.
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