A new approach to controlling haemolysis

One of the most frustrating aspects of the management of PNH has been, until now, the absence of an effective way to control haemolysis. Eculizumab, a humanized antibody against complement protein C5 that inhibits the activation of terminal components of complement, has been tested in a small group of transfusion-dependent PNH patients. The results thus far appear very promising; indeed, reduced intravascular haemolysis and less haemoglobinuria have been documented, as well as a marked decrease in transfusion requirement in most patients.

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