Contents

Contributors, viii

Preface to the fifth edition, xii

Preface to the first edition, xiii

1 Stem cells and haemopoiesis, 1 Myrtle Gordon

2 Erythropoiesis, 13

Douglas R Higgs and William G Wood

3 Iron metabolism, iron deficiency and disorders of haem synthesis, 26

Mark Worwood and A Victor Hoffbrand

4 Iron overload, 44

A Victor Hoffbrand and Mark Worwood

5 Megaloblastic anaemia, 60

A Victor Hoffbrand and Ralph Green

6 Haemoglobin and the inherited disorders of globin synthesis, 85

David J Weatherall

7 Sickle cell disease, 104 Ashutosh Lal and Elliott P Vichinsky

8 Hereditary disorders of the red cell membrane, 119 Edward C Gordon-Smith

9 Disorders of red cell metabolism, 133 Edward C Gordon-Smith

10 Acquired haemolytic anaemias, 151 Edward C Gordon-Smith and Judith CWMarsh

11 Paroxysmal nocturnal haemoglobinuria, 169 Lucio Luzzatto and Rosario Notaro

12 Inherited aplastic anaemia/bone marrow failure syndromes, 176

Inderjeet S Dokal

13 Acquired aplastic anaemia, other acquired bone marrow failure disorders and dyserythropoiesis, 190 Edward C Gordon-Smith and Judith CW Marsh

14 Red cell immunohaematology: introduction, 207

Marcela Contreras and Geoff Daniels

15 Antigens in human blood, 225

Marcela Contreras and Geoff Daniels

16 Clinical blood transfusion, 249 Marcela Contreras, Clare PF Taylor and John A Barbara

17 Phagocytes, 277

Farhad Ravandi and Ronald Hoffman

18 Haemopoietic growth factors, 303 Jenny L Byrne and Nigel H Russell

19 Lysosomal storage disorders, 318 Atul B Mehta and Derralynn A Hughes

20 Normal lymphocytes and non-neoplastic lymphocyte disorders, 330

Mark T Drayson and Paul AH Moss

21 The spleen, 358 S Mitchell Lewis

22 Immunodeficiency diseases, 370 A David B Webster

23 Haematology in HIV disease, 380 Christine Costello

24 Histocompatibility, 395 Ann-Margaret Little, Steven GE Marsh and J Alejandro Madrigal

25 Stem cell transplantation, 419

Charles Craddock and Ronjon Chakraverty

26 Non-myeloablative transplantation, 436 Kirsty J Thomson, Michael Potter and Stephen Mackinnon

27 Gene therapy of haemopoietic disorders, 449 Raphaƫl F Rousseau and Malcolm K Brenner

28 The molecular basis of leukaemia and lymphoma, 462 Peter J Campbell, Anthony J Bench and

Anthony R Green

29 Diagnosis and classification of acute leukaemia, 476 Barbara J Bain

30 Cytogenetics of leukaemia and lymphoma, 492 Christine J Harrison

31 Acute myeloid leukaemia, 509 Alan K Burnett

32 Adult acute lymphoblastic leukaemia, 525 Dieter Hoelzer and Nicola Gokbuget

33 Childhood acute lymphoblastic leukaemia, 542 Der-CherngLiang and Ching-Hon Pui

34 Minimal residual disease in acute leukaemia, 561 Letizia Foroni, Paula M Gameiro and

A Victor Hoffbrand

35 Multidrug resistance in leukaemia, 575 Jean-Pierre Marie and Ollivier Legrand

36 Supportive care in the management of leukaemia, 586 Archibald G Prentice and J Peter Donnelly

37 Chronic myeloid leukaemia, 603 John M Goldman and Tariq I Mughal

38 Chronic lymphocytic leukaemia and other B-cell disorders, 619

Daniel Catovsky

39 T-cell lymphoproliferative disorders, 644 Estella Matutes

40 The myelodysplastic syndromes, 662 David G Oscier and Sally B Killick

41 Myeloma, 681

Evangelos Terpos and Amin Rahemtulla

42 Amyloidosis, 703

Hugh JB Goodman and Philip NHawkins

43 The classification of lymphoma, 714 Peter G Isaacson

44 Hodgkin's lymphoma, 722 Lynny Yung and David Linch

45 Aetiology and management of non-Hodgkin's lymphoma, 735

Irit Avivi and Anthony H Goldstone

46 Myeloproliferative disorders, 761 George Vassiliou and Anthony R Green

47 Normal haemostasis, 783

Geoffrey Kemball-Cook, Edward GD Tuddenham and John H McVey

48 The vascular function of platelets, 808 Stephen P Watson and Paul Harrison

49 Inherited bleeding disorders, 825 Michael A Laffan and Christine A Lee

50 Congenital bleeding: autosomal recessive disorders, 842

Flora Peyvandi and Pier M Mannucci

51 Acquired coagulation disorders and vascular bleeding, 859

Michael J Nash, Hannah Cohen, Ri Liesner and Samuel J Machin

52 Thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome (congenital and acquired), 876

Pier M Mannucci and Flora Peyvandi

53 Inherited thrombophilia, 885 Isobel D Walker

54 Acquired venous thrombosis, 900 Beverley J Hunt and Michael Greaves

55 Management of venous thromboembolism, 912 Sam Schulman

56 Congenital platelet disorders, 925 Maurizio Margaglione

57 Immune thrombocytopenic purpura: pathophysiology in patients with persistent problems, 937

April Chiu, Wayne Tam, Doug Cines and James B Bussel

58 Atherothrombosis, thrombolysis and anti-platelets, 945

Lucinda KM Summers, Stephen P Marso and Peter J Grant

59 Haematological aspects of systemic disease, 965 Atul B Mehta and A Victor Hoffbrand

60 Haematological aspects of tropical diseases, 979 Imelda Bates and Ivy Ekem

61 Neonatal haematology, 994 Irene AG Roberts

62 Laboratory practice, 1007 S Mitchell Lewis

Appendix 1: Normal values, 1022

Appendix 2: WHO classification of tumours of haemopoietic and lymphoid tissues, 1023

Index, 1025

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