Differentiation of haemopoietic stem cells to form erythroid progenitors

Figure 2.2 Summary of some steps in self-renewal, lineage specification and differentiation of haemopoietic stem cells to red cells. Some of the key transcription factors involved in this process are summarized underneath.

Self-renewal c*

Lymphoid lineages

Other myeloid lineages

CFU-GEMM BFU-E

CFU-E

Key transcription factors

Key transcription factors

188 h

60 h

30 h

Erythron i r

Frequency per 104

~1

~1

4-10

20-60

50-60

400

500

1000

nucleated bm cells

% cells in cycle

Low

15-20

30-40

60-70

60

70

80

0

CD34

++

+++

++

±

-

-

-

-

CD71 (TfR)

±

±

±

++

+++

+++

+++++

++

+

EpoR

-

-

++

++

++

±

±

-

GPA

-

-

±

+

++++

++++

++++

++++

++++

Globin mRNA

-

-

--

-

+

+

+++

+++++

++

Hb

-

-

--

-

±

+

+++

+++++

+++++

Progenitors 1 1 Precursors

HSC CFU-GEMM BFU-E BFU-E CFU-E Pro Bas Early Late Retic RBC Early Late Pol Ort

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