This is a condition that is recognized at birth but may occur in utero. It is characterized by heavy parenchymal iron deposition in several organs and irreversible liver failure. The only therapeutic option used to be liver transplantation. Neonatal haemo-chromatosis has been linked in some cases to the presence of a maternal factor, e.g. an antiribonuclear factor antibody. Infusions of gammaglobulin in pregnancy appear to reduce the severity of the condition and it has been proposed that the disease is due to an alloantibody (as rhesus incompatibility) but the target antigen is unknown. No mutations in the HFE gene are reported and chromosome 1q linkage has been excluded.
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