Secondary defects in cellular immunity

Figure 22.2 The stages in B-cell development. Genetic defects in molecules associated with arrest at various stages are shown in the coloured boxes. RAG, recombinase activating gene; |l mem, membrane-associated || chain; C|l, cytoplasmic | expression; Btk, Bruton's tyrosine kinase; BLNK, B cell linker protein; ICOS, human inducible co-stimulator; AID, activation-induced cytidine deaminase; UNG, uracil-DNA glycosylase; BAFF-R, B-cell activation factor from the tumour necrosis factor family; TAC-I, transmembrane activator and calcium modulator and cyclophilin ligand interactor.

ProB

IL-7Ra

ProB

IL-7Ra

CD19

RAG1+2

CD19

RAG1+2

PreB-1

PreB-1

Immature B

Mature B

PreB-11

PreB-11

RAG1+2

High-affinity antibodies

SIgM

Btk BLNK

Somatic hypermutation

Class switch recombination of B cells in germinal centres

CD40L

CD40

ICOS

AID

UNG

Baff-R

Plasma cells

IgG/IgA

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