Selected bibliography

CHAPTER 3

Iron metabolism, iron deficiency and disorders of haem synthesis

Mark Worwood and A Victor Hoffbrand

Introduction, 26 Distribution of body iron, 26

Functional iron-containing proteins, 26 Ferritin and haemosiderin, 27 Transferrin and transferrin receptors, 27 Intracellular transit iron and plasma non-transferrin-bound iron, 29 Cellular iron homeostasis, 29 Normal iron balance, 30 Iron absorption, 30 Dietary and luminal factors, 30 Mucosal factors: molecular aspects of iron absorption and its regulation, 31 Regulation of iron absorption, 32

Internal iron exchange, 32

Iron uptake by erythroid cells, 32 Breakdown of haemoglobin iron, 33 Role of liver, 33

Fate of iron in the erythroid cell, 33 Haem synthesis, 33 Control mechanisms in haem synthesis, 33 Diagnostic methods for investigating iron metabolism, 34 Storage iron, 34 Iron supply to the tissues, 35 Iron deficiency anaemia, 36 Sequence of events, 36

Causes of iron deficiency, S?

Increased physiological iron requirements, S? Blood loss, S? Malabsorption, S?

Management of iron deficiency, S?

Oral therapy, S? Parenteral iron therapy, S8 Pathological alterations in haem synthesis, S9

Porphyrias, S9 Lead poisoning, 4C Sideroblastic anaemia, 4C Selected bibliography, 42

Causes of iron deficiency, S?

Increased physiological iron requirements, S? Blood loss, S? Malabsorption, S?

Management of iron deficiency, S?

Oral therapy, S? Parenteral iron therapy, S8 Pathological alterations in haem synthesis, S9

Porphyrias, S9 Lead poisoning, 4C Sideroblastic anaemia, 4C Selected bibliography, 42

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